House

Season 6 Episode 4 was called "The Doctor's Wife" if you're a Whovian, you'll know it.

In this episode, The Doctor, Amy and Rory travel outside the universe, and meet some very interesting folks. Their names were Auntie and Uncle.

Auntie and Uncle

Rather upbruptly they meet, Idris. They don't know until later but she is the Tardis, in a matter of speaking. House, the villain in the episode, is the planet that they landed on. But it has a conscience, and he can talk. On House's orders Nephew (the ood on the planet) empties Idris' mind from her body and fills it with the Tardis matrix.

The Doctor and his wife, Idris

House was able to separate Amy and Rory from the Doctor when the two of them went back to the Tardis. House plays evil little tricks on Amy and Rory, using the Tardis. House does things like blinding Amy and tricking her into thinking Rory has been in the Tardis for 50 years, alone.

House eventually steals the Doctor's Tardis with Amy and Rory along with it. The Doctor and Idris build a new Tardis out of Tardis pieces and save Amy and Rory from House.

Unfortunately, the Tardis matrix has to leave Idris, so the Doctor loses his "wife", but he will always have the Tardis.

The trailer for this episode is beneath this sentence, it includes scenes from when House terrorizes Amy and Rory, as well as some creepy voice overs from House himself.